ACUTE EFFECTS OF GUARANA ON PHYSIOLOGICAL RESPONSES, EXERTION, AND PERFORMANCE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Authors

DOI:

https://doi.org/10.31512/vivencias.v22i46.1754

Abstract

We aimed to perform a systematic review with meta-analysis of studies that tested the acute effects of guarana supplementation or guarana-added compounds on physiological responses, perceived exertion and exercise performance in healthy adults. This review (CRD42021249569) was performed according to Cochrane recommendations, with searches performed in electronic databases (PubMed, Web of Science, Embase, SportDiscus, and BIREME). Syntheses of data from included studies were performed, and the RoB-2 tool was used to assess the risk of bias. Assessed outcomes were: 1) perceived exertion; 2) exercise performance parameters: peak power (PPO), fatigue, speed, strength, total work and vertical jump height; 3) physiological parameters: heart rate (HR), respiratory exchange ratio (RER), maximal oxygen uptake (VO2max), peak oxygen uptake (VO2peak), glucose and lactate threshold. Available data were pooled through meta-analysis. A significant effect was observed for reduced perceived exertion (SMD: -1.32; 95% CI: -1.85 to -0.79; p < 0.01; I² = 36%), while no effects were detected on heart rate (SMD: -0.18; 95% CI: -0.77 to 0.42; p = 0.56; I² = 0%) following guarana supplementation during exercise. Qualitative analysis indicated that guarana supplementation led to a reduction in fatigue levels (25.30%), an increase in peak power output (PPO) during anaerobic exercise (2.57%), and an increase in total work performed (4%). However, no effects were observed on PPO during aerobic exercise, VO2max, VO2peak, glucose levels, respiratory exchange ratio (RER), lactate threshold, vertical jump performance, or agility tasks.

Author Biographies

Igor Martins Barbosa, Universidade Federal de Santa Maria, Brasil

Doutorando em Farmacologia na Universidade Federal de Santa Maria

Gabriel Rigo Weber, Universidade Federal de Santa Maria, Brasil

Bacharel em Educação Física pela Universidade Federal de Santa Maria.

Marcelo Henrique Glanzel, Universidade Federal do Rio Grande do Sul, Brasil

Doutorando em Ciências do Movimento Humano pela Universidade Federal do Rio Grande do Sul (UFRGS) e Professor Assistente do Curso de Educação Física da UNISC.

Carlos Fernando de Mello, Universidade Federal de Santa Maria, Brasil

Professor Titular do Departamento de Fisiologia e Farmacologia da Universidade Federal de Santa Maria

References

ALKHATIB, A.; SEIJO, M.; LARUMBE, E.; NACLERIO, F. Acute effectiveness of a "fat-loss" product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise. J Int Soc Sports Nutr, 12, p. 44, 2015. https://doi.org/10.1186/s12970-015-0105-8

ALTMANN, S. et al. Validity and reliability of speed tests used in soccer: A systematic review. PLoS One, 14, n. 8, p. e0220982, 2019. https://doi.org/10.1371/journal.pone.0220982

ARNAUD, M. J. The pharmacology of caffeine. Prog Drug Res, 31, p. 273-313, 1987. https://link.springer.com/content/pdf/10.1007/978-3-0348-9289-6_9.pdf

BURKE, L. M. Caffeine and sports performance. Appl Physiol Nutr Metab, 33, n. 6, p. 1319-1334, Dec 2008. https://doi.org/10.1139/H08-130

COHEN, J. Statistical power analysis for the behavioral sciences. 2. ed. Hillsdale: Lawrence Erlbaum Associates, 1988. https://doi.org/10.4324/9780203771587

DE ARAUJO, D. P. et al. The use of guarana (Paullinia cupana) as a dietary supplement for fatigue in cancer patients: a systematic review with a meta-analysis. Support Care Cancer, 29, n. 12, p. 7171-7182, Dec 2021. https://doi.org/10.1007/s00520-021-06242-5

DJORDJEVIC, N. et al. Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes. Eur J Clin Pharmacol, 64, n. 4, p. 381-385, Apr 2008. https://doi.org/10.1007/s00228-007-0438-6

GALDURÓZ, J. C.; CARLINI, A. Acute effects of the Paulinia cupana, "Guaraná" on the cognition of normal volunteers. Sao Paulo Med J, 112, n. 3, p. 607-611, Jul-Sep 1994. https://pesquisa.bvsalud.org/portal/resource/pt/lil-147281

GHOTBI, R. et al. Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur J Clin Pharmacol, 63, n. 6, p. 537-546, Jun 2007. https://doi.org/10.1007/s00228-007-0288-2

GLAISTER, M. et al. The Effects of Caffeine Supplementation on Physiological Responses to Submaximal Exercise in Endurance-Trained Men. PLoS ONE, 11, n. 8, 2016. https://doi.org/10.1371/journal.pone.0161375

GLAISTER, M.; GISSANE, C. Caffeine and Physiological Responses to Submaximal Exercise: A Meta-Analysis. Int J Sports Physiol Perform, 13, n. 4, p. 402-411, Apr 2018. https://doi.org/10.1123/ijspp.2017-0312

GRGIC, J. et al. Wake up and smell the coffee: caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses. Br J Sports Med, 54, n. 11, p. 681-688, Jun 2020. https://doi.org/10.1136/bjsports-2018-100278

GUENGERICH, F. P. Cytochrome p450 and chemical toxicology. Chem Res Toxicol, 21, n. 1, p. 70-83, Jan 2008. https://doi.org/10.1021/tx700079z

GUEST, N. S. et al. International society of sports nutrition position stand: caffeine and exercise performance. J Int Soc Sports Nutr, 18, n. 1, p. 1, Jan 2021. https://doi.org/10.1186/s12970-020-00383-4

GURNEY, T.; BRADLEY, N.; IZQUIERDO, D.; RONCA, F. Cognitive effects of guarana supplementation with maximal intensity cycling. British Journal of Nutrition, 130, n. 2, p. 253-260, 2023. https://doi.org/10.1017/S0007114522002859

HACK, B. et al. Effect of Guarana (Paullinia cupana) on Cognitive Performance: A Systematic Review and Meta-Analysis. Nutrients, 15, n. 2, Jan 2023. https://doi.org/10.3390/nu15020434

HASKELL, C. F. et al. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans. J Psychopharmacol, 21, n. 1, p. 65-70, Jan 2007. https://doi.org/10.1177/0269881106063815

HIGGINS, J. P.; THOMPSON, S. G.; DEEKS, J. J.; ALTMAN, D. G. Measuring inconsistency in meta-analyses. Bmj, 327, n. 7414, p. 557-560, Sep 2003. https://doi.org/10.1136/bmj.327.7414.557

HIGGINS, J. P. T.; THOMAS, J.; CHANDLER, J.; CUMPSTON, M.; LI, T.; PAGE, M. J.; WELCH, V. A. (ed.). Cochrane Handbook for Systematic Reviews of Interventions. 2. ed. Chichester: John Wiley & Sons, 2019. https://onlinelibrary.wiley.com/doi/book/10.1002/9781119536604?msockid=224029c8b67d6fde297a3d12b7c96e62

KACZKA, P. et al. Acute Effect of Caffeine-Based Multi-Ingredient Supplement on Reactive Agility and Jump Height in Recreational Handball Players. Nutrients, 14, n. 8, Apr 2022. https://doi.org/10.3390/nu14081569

KENNEDY, D. O. et al. Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guaraná (Paullinia cupana). Appetite, 50, n. 2-3, p. 506-513, Mar-May 2008. https://doi.org/10.1016/j.appet.2007.10.007

KENNEDY, D. O.; HASKELL, C. F.; WESNES, K. A.; SCHOLEY, A. B. Improved cognitive performance in human volunteers following administration of guarana (Paullinia cupana) extract: comparison and interaction with Panax ginseng. Pharmacol Biochem Behav, 79, n. 3, p. 401-411, Nov 2004. https://doi.org/10.1016/j.pbb.2004.07.014

MCLELLAN, T. M.; CALDWELL, J. A.; LIEBERMAN, H. R. A review of caffeine's effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev, 71, p. 294-312, Dec 2016. https://doi.org/10.1016/j.neubiorev.2016.09.001

MIELGO-AYUSO, J. et al. Caffeine Supplementation and Physical Performance, Muscle Damage and Perception of Fatigue in Soccer Players: A Systematic Review. Nutrients, 11, n. 2, Feb 2019. https://doi.org/10.3390/nu11020440

PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj, 372, p. n71, Mar 2021. https://doi.org/10.1136/bmj.n71

PENNA, E. M. et al. Guarana (Paullinia cupana) but Not Low-Dose Caffeine Improves Cycling Time-Trial Performance Versus Placebo. Int J Sport Nutr Exerc Metab, 34, n. 1, p. 30-37, Jan 2024. https://doi.org/10.1123/ijsnem.2023-0148

POMPORTES, L. et al. Cognitive Performance Enhancement Induced by Caffeine, Carbohydrate and Guarana Mouth Rinsing during Submaximal Exercise. Nutrients, 9, n. 6, Jun 2017. https://doi.org/10.3390/nu9060589

POMPORTES, L.; BRISSWALTER, J.; HAYS, A.; DAVRANCHE, K. Effects of Carbohydrate, Caffeine, and Guarana on Cognitive Performance, Perceived Exertion, and Shooting Performance in High-Level Athletes. Int J Sports Physiol Perform, 14, n. 5, p. 576-582, May 2019. https://doi.org/10.1123/ijspp.2017-0865

POMPORTES, L. et al. Heart rate variability and cognitive function following a multi-vitamin and mineral supplementation with added guarana (Paullinia cupana). Nutrients, 7, n. 1, p. 196-208, Dec 2014. https://doi.org/10.3390/nu7010196

RONGEN, G. A. et al. Effect of adenosine on heart rate variability in humans. Clin Sci (Lond), 96, n. 6, p. 597-604, Jun 1999. https://pubmed.ncbi.nlm.nih.gov/10334965/

SACHSE, C.; BROCKMÖLLER, J.; BAUER, S.; ROOTS, I. Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol, 47, n. 4, p. 445-449, Apr 1999. https://doi.org/10.1046/j.1365-2125.1999.00898.x

SCHIMPL, F. C.; DA SILVA, J. F.; GONÇALVES, J. F.; MAZZAFERA, P. Guarana: revisiting a highly caffeinated plant from the Amazon. J Ethnopharmacol, 150, n. 1, p. 14-31, Oct 2013. https://doi.org/10.1016/j.jep.2013.08.023

SOUTHWARD, K.; RUTHERFURD-MARKWICK, K. J.; ALI, A. The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis. Sports Med, 48, n. 8, p. 1913-1928, Aug 2018. https://doi.org/10.1007/s40279-018-0939-8

STERNE, J. A. C. et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. Bmj, 366, p. l4898, Aug 2019. https://doi.org/10.1136/bmj.l4898

TORRES, E. et al. Effects of the consumption of guarana on human health: A narrative review. Compr Rev Food Sci Food Saf, 21, n. 1, p. 272-295, Jan 2022. https://ift.onlinelibrary.wiley.com/doi/epdf/10.1111/1541-4337.12862

VEASEY, R. C. et al. The Effects of Supplementation with a Vitamin and Mineral Complex with Guaraná Prior to Fasted Exercise on Affect, Exertion, Cognitive Performance, and Substrate Metabolism: A Randomized Controlled Trial. Nutrients, 7, n. 8, p. 6109-6127, Jul 2015. https://doi.org/10.3390/nu7085272

VIANI, R. The metabolism of coffee constituents. In: CLARKE, R. J.; MACRAE, R. (eds.). Coffee. Physiology. London: Elsevier Applied Sciences, 1988. p. 1-31. https://link.springer.com/book/9781851661862

WAX, B. et al. Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients, 13, n. 6, Jun 2021. https://doi.org/10.3390/nu13061915

WIKOFF, D. et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol, 109, n. Pt 1, p. 585-648, Nov 2017. https://doi.org/10.1016/j.fct.2017.04.002

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Published

2026-06-06

How to Cite

Barbosa, I. M., Weber, G. R., Glanzel, M. H., & Mello, C. F. de. (2026). ACUTE EFFECTS OF GUARANA ON PHYSIOLOGICAL RESPONSES, EXERTION, AND PERFORMANCE: A SYSTEMATIC REVIEW AND META-ANALYSIS. Vivências, 22(46), 249–264. https://doi.org/10.31512/vivencias.v22i46.1754

Issue

Vol. 22 No. 46 (2026)

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ARTIGOS DE FLUXO CONTÍNUO

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Copyright (c) 2026 Igor Martins Barbosa, Gabriel Rigo Weber, Marcelo Henrique Glanzel, Carlos Fernando de Mello

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